LDC000067

Product Name: LDC000067
CAS No.: 1073485-20-7
Chemical Name: LDC000067
Synonyms: LDC067;CS-1535;LDC-067;LDC 067;LDC000067;LDC000067(LDC-067);LDC000067 USP/EP/BP;LDC067;LDC 000067;LDC-000067;LDC 067;LDC-067;(3-(6-(2-Methoxyphenyl)pyrimidin-4-ylamino)phenyl)methanesulfonamide;3-[[6-(2-methoxyphenyl)-4-pyrimidinyl]amino]-benzenemethanesulfonamide
CBNumber: CB12716267
Molecular Formula: C18H18N4O3S
Formula Weight: 370.43
MOL File: 1073485-20-7.mol

More

Less

LDC000067 Property

Boiling point:: 604.1±65.0 °C(Predicted)
Density: 1.360±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
solubility: insoluble in H2O; insoluble in EtOH; ≥18.52 mg/mL in DMSO
form: Powder
pka: 10.27±0.60(Predicted)

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 29419
Product name: LDC000067
Packaging: 5mg
Price: $81
Updated: 2024/03/01

Cayman Chemical

Product number: 29419
Product name: LDC000067
Packaging: 25mg
Price: $317
Updated: 2024/03/01

Cayman Chemical

Product number: 29419
Product name: LDC000067
Packaging: 10mg
Price: $143
Updated: 2024/03/01

Tocris

Product number: 6752
Product name: LDC000067
Purity: ≥98%(HPLC)
Packaging: 25
Price: $316
Updated: 2021/12/16

AK Scientific

Product number: 2509AH
Product name: (3-((6-(2-Methoxyphenyl)pyrimidin-4-yl)amino)phenyl)methane
Packaging: 10mg
Price: $177
Updated: 2021/12/16

More

Less

LDC000067 Chemical Properties,Usage,Production

Biological Activity

ldc000067 (ldc067) is a novel specific inhibitor of cdk9 with ic50 value of 44 ± 10 nm [1].cyclin-dependent kinase 9 (cdk9) is a cyclin-dependent kinase. cdk9 and cyclin t form the positive transcription elongation factor b (p-tefb) complex for rna polymerase ii and functions by phosphorylating the c-terminal domain of the largest subunit of rna polymerase ii [1].ldc000067 (ldc067) is a novel and highly specific cdk9 inhibitor. ldc000067 exhibited selectivity for cdk9 over other cdks in the range of 55-fold (vs. cdk2) to over 230-fold (vs. cdk6 and cdk7). ldc067 also inhibited transcription in a dose-dependent and atp-competitive manner. in whole cells, ldc000067 induced the tumor suppressor protein p53 activation and apoptosis. ldc000067 also selectively reduced short-lived mrnas, including those that encode regulators of apoptosis and proliferation such as myc and mcl1 [1].

in vitro

LDC000067 reduces Ser2-P in mESCs, induces p53 activation, and leads to apoptosis. In addition, LDC067 also dose-dependently inhibited the de novo RNA synthesis of P-TEFb-dependent cellular genes.

target

Target	Value
CDK9 (Cell-free assay)	44 nM
CDK2 (Cell-free assay)	2.441 μM

storage

Store at -20°C

References

[1]. albert tk, rigault c, eickhoff j, et al. characterization of molecular and cellular functions of the cyclin-dependent kinase cdk9 using a novel specific inhibitor. br j pharmacol, 2014, 171(1): 55-68.

LDC000067 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

LDC000067 Suppliers

China 70 India 1 United States 13 Global 84

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4863
Advantage: 58

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2784
Advantage: 58

BOC Sciences

Tel: 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 9926
Advantage: 65

Target molecule Corp.

Tel: 857-239-0968
Fax: 857-239-8801
Email: service1@targetmol.com
Country: United States
ProdList: 2559
Advantage: 60

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4662
Advantage: 60

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6393
Advantage: 58

Cckinase, Inc.

Tel: +1 (732)236-3202
Email: sales@cckinase.com
Country: United States
ProdList: 2738
Advantage: 58

Aladdin Scientific

Tel: +1-833-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57511
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354
Email: support@targetmol.com
Country: United States
ProdList: 19973
Advantage: 58

More

Less

View Lastest Price from LDC000067 manufacturers

Career Henan Chemical Co

Product: (3-(6-(2-Methoxyphenyl)pyrimidin-4-ylamino)phenyl)methanesulfonamide 1073485-20-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: Min98% HPLC
Supply Ability: g/kg/ton
Release date: 2020-01-01

1073485-20-7, LDC000067Related Search:

Diphenhydramine Sulfadiazine p-Anisidine Pictilisib Ribociclib BS-181 HCl (2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol Abemaciclib mesylate (LY2835219) PHA 767491 HYDROCHLORIDE

LDC000067

LDC 067

LDC067

LDC-067

(3-(6-(2-Methoxyphenyl)pyrimidin-4-ylamino)phenyl)methanesulfonamide

3-[[6-(2-methoxyphenyl)-4-pyrimidinyl]amino]-benzenemethanesulfonamide

LDC067;LDC 000067;LDC-000067;LDC 067;LDC-067

CS-1535

LDC000067(LDC-067)

Benzenemethanesulfonamide, 3-[[6-(2-methoxyphenyl)-4-pyrimidinyl]amino]-

LDC000067 USP/EP/BP

LDC000067,CDK,LDC-067,Apoptosis,Cyclin dependent kinase,LDC 000067,LDC-000067,inhibit,LDC 067,Inhibitor

1073485-20-7

Inhibitors

API